Comprehensive Developmental based approaches such as DIR/Floortime are strongly grounded in infant and early childhood mental health, clinical and developmental psychology and the neurosciences. They are peer reviewed evidenced based approaches to treat children and older with autism spectrum disorder and other biopsychosocial based challenges. Below are several resources that validate a comprehensive DIR/Floortime developmental based approach to treat children with ASD and other biopsychosocial based challenges and the neuroscientific foundations that justify its use as a primary intervention approach with children and families.
In 2011 preliminary results from a fully randomized control trial of 51 children with mild to severe autism, ages 2 years 0 months to 4 years 11 months, were published by the MEHRI Foundation at York University, Canada. Participants were assigned to either a target treatment group (DIR Floortime, 25 children) or community treatment group (26 children, 16 received ABA). The study evaluated a social-communication based approach to autism. PET scans of all children were taken prior to trial start and post trial to record any neuronal changes. What was quite remarkably demonstrated were clinically significant and meaningful structural changes in formerly underactive and overactive areas of brain functioning among participants in the targeted treatment group.
Data sets among participants in the targeted DIR/Floortime treatment group (one child here presented in video below) revealed significant increased activity in the prefrontal cortex area (e.g., executive functioning responsible for emotional regulation, ideation, motor planning and sequencing); significantly reduced activity in subcortical area (e.g., reduced size and activity of the amygdala responsible for All or Nothing responses); increased activity and functioning in FFA (fusiform face area of the fusiform gyrus responsible for reading and interpreting the emotions/faces of others). New areas of activity in brain functioning were consistent with what we see with typical healthy developing children. All of the above functional changes directly correlated with social-communication gains which were demonstrated in the targeted treatment group vs. the community group where little if any neuronal structural changes were observed. Re-analysis of trial result data in 2015 further revealed that the targeted treatment group considerably outperformed the community group on number of utterances produced and various speech act categories.
Published preliminary and follow up data on the 2011 MEHRI Foundation study (cited above) and other previous and/or ongoing controlled randomized trials supporting a comprehensive developmental based approach, such as DIR/Floortime as a primary treatment methodology for young children and older diagnosed with ASD can be found at http://www.icdl.com/research
The following is a one hour and forty minute talk with video presentation given by one the most international renown Occupational therapist and the DIR/Floortime approach, Rosemary White., OTR/L. This talk and video presentation is extraordinary useful for both families and clinicians as Rosemary explains in a remarkably concise and detailed perspective the theory of DIR/Floortime methodology in everyday practice.
Below are the Clinical Practice Guidelines of the Interdisciplinary Council Developmental Learning (ICDL) published in 2001. It is a comprehensive overarching view of the biopsychosocial components which form the neuroscientific foundations for a comprehensive Developmental assessment and treatment approach for individuals diagnosed with autism spectrum and other biopsychosocial challenges. The chief editor is the late Dr. Stanley Greenspan, M.D. (former head of NIMH, Mental Health Study Center and the Clinical Infant Development; co-founder of Interdisciplinary Council Developmental Learning and DIR/Floortime). It is co-authored by many of the foremost professionals within the biopsychosocial sciences.
The following white paper by Diane Cullinane, M.D. is an overview of the scientific evidentiary support for the DIR/Floortime methodology to treat infants, toddlers and older with ASD and related affect-sensory and social pragmatic communication based challenges:
http://www.adaptmanitoba.ca/wp-content/uploads/2014/04/Evidence_Base_for_DIR-2014.pdf Updated, July 2017: https://docs.google.com/a/icdl.com/viewer?a=v&pid=sites&srcid=aWNkbC5jb218aWNkbHxneDozNzJiNGQxYzQyMWEzZTIx
It is extremely valuable for all primary caregivers and clinicians working with infants, toddlers, older children and adults with ASD to begin to read the voluminous evidenced-based research that supports not the older traditional and essentially simplistic behavioral based models (ABA) but rather comprehensive evidenced-based Developmental social pragmatic approaches, such as DIR/ Floortime, which address not targeted or circumscribed behaviors but the primary core Developmental challenges associated with ASD. The latter unlike traditional behavioral based (ABA) models do not render or conflate a false evidentiary equivalence between the biopsychosocial complexity of each child's core Developmental capacities and individual sensory-affect-motor processing differences with the acquisition of the child's conditioned (on cue) environmental responses or what colleagues and I refer to as "surface trained behaviors. "
Instead, developmental approaches such as DIR/Floortime focus on the core Developmental foundations of social-emotional relating, thinking and communicating . Thus, they are entirely centered around the child's executive functioning (child's emerging "sense of self") guided by the child's individual processing differences and addressed in the context of child/primary caregiver relationships. It is not the isolation or generalization of trained or memorized "targeted behaviors" but the synchronization of primary caregivers' guided to learn how to connect and engage with their child's developmental and sensory-affect-motor processing challenges that significantly enables the strengthening of underlying neuronal pathways that lead toward the formation of new synaptic connections and meaningful Developmental milestone advance.
Neurotypical Development: Birth to Three.
The neuroscientific evidence over the last several decades clearly demonstrates a direct correlation between forming healthy neuronal [brain] patterns of connectivity and child/primary caregiver nurturance based practices: The nature of child/caregiver deepening affect reciprocal attachment and complex two-way reciprocal emotional problem solving (i.e., motor planning and sequencing; co-referencing with affective gestures) with respect to building the foundations of the child's healthy core "sense of self" and correspondingly the child's intact, integrated and healthy emerging developmental milestones (i.e., social-emotional relating thinking and communicating) have been well established in the fields of infant mental health, clinical and developmental psychology. Since the 1990's this has been corroborated by research data in neuroscience which clearly demonstrates that the healthy integration of each infant's sensory and motor connections and how these inchoate connections (loosely formed neural pathways) from birth form into complex synaptic patterns (the wiring of the neural pathways) are directly dependent upon highly emotionally attuned and responsive primary caregiver interactions. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318551/
This overarching epigenetic (infant/parent dyadic) framework can be correctly conceived of in terms of a bridging of the fields of Developmental psychology and neurobiology with respect towards a greater understanding and integration of the biological, psychological-and-social dynamics of interaction. Due to the advances in technology over the last twenty-five years we can now consistently measure in real-time (i.e., fMRI )the impact between actual neuronal activity (i.e., synaptic formation and interconnectivity across different part of the brain) and healthy child/caregiver nurturance based practices or conversely impaired neuronal activity due to unhealthy nurturance practices. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968319/ http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181066
Provided below are several links to some audio and video discussions for families and clinicians working in the field on what actually constitutes the healthy affective basis of childhood development (i,e., the roots of emotional intelligence). Now, given a child's healthy underlying biological and immune system, the perennial question prior to 1990's was, "What is it that brings the early developing parts of the infant's brain (primitive reflexes, senses and emotions: breathing, blinking, sensations to sense of touch warmth; auditory, soothing or alarming voice, vision, etc.) into organized and meaningful affective patterns of simple reciprocal co-regulated engagement (optimal arousal for attending, relating and engaging)?" The answer given by neuroscience is the co-regulated partner or "adult higher brain" (the primary caregiver) with the post utero or newly forming brain of the child. This is the foundational social-emotional symbiotic relationship critical for all infant/toddler development otherwise known as the infant/parent dyad.
Again, what is required to bring the emerging "social brain" of the infant online with respect to basic executive functioning from simple to increasingly complex engagement with others (e.g., regulated/co-regulated sensory-affect-motor planning and sequencing and engagement) is the more experienced or higher brain of the primary caregiver or more specifically the child/primary caregiver dyadic interaction, Every human infant is born with 100 billion neurons. The human infant is born equipped with basic primitive reflexes. senses and emotional responses. However, the vast majority of those neuronal pathways are loosely wired together at birth and begin to increasingly coalesce into more mature synaptic sequences during the first several years of life. The brain is experience-user/interdependent. The strength of the connectivity and resiliency of brain's foundations (primitive, limbic and neocortex) are directly co-determined or co-regulated by the "higher brain" of the parent or the child/primary caregiver dyadic interaction. This includes deepening attachment, attunement and reciprocal emotional social engagement (i.e., beginning from birth with wooing/pleasurable co-affective back and forth emotional signaling between parent and infants such as "peek-a-boo", etc).
However, it is notable that what has been far too long ignored in practice by special educators and other clinicians working with children with autism spectrum and other related challenges and too often if at all conveyed to parents (i.e., at the start of early intervention) is the neuroscientific evidence that it is precisely these same principles of healthy nurturance based practices - necessary and indeed critical for each child's core functional emotional developmental milestones (i.e., calm, attentiveness, co-regulated patterns of back and forth emotional regulation, playfulness, ideation) when applied in a therapeutic context (i.e., adjusted or tailored to each child's biological based functional emotional developmental and processing challenges) that does in fact significantly help re-construct new healthy neuronal pathways in the brain.
Guided pleasurable and affectively emotionally-engaging relationships not just with infants but with older children with mild to more involved autism spectrum challenges (due to the brain's enormous neuroplasticity) can not only help facilitate but again as the neuroscientific evidence clearly demonstrates actually re-wire the brain, that is build, strengthen and expand those healthy neural pathways (e.g., improved connectivity between the prefrontal cortex and subcortical functioning and overall integrated sensory-affect-motor functioning). An expanding database of evidence over the last decade on neuroplasticity is increasingly demonstrating the ability for individuals to re-construct new neuronal connections throughout the lifespan.
The following is an extremely enlightening discussion with regards to much of what I have discussed above with Dr. Stuart Shanker, Distinguished Research Professor of Philosophy and Psychology at York University, entitled Babies, Brain, Nature and Nurture.
Dr. Stuart Shanker discussing from a biopsychosocial perspective the true definition, meaning and nature of what Self-Regulation is: https://www.youtube.com/watch?v=84GHcfzXsmw
Susan Hopkins EdD and Elizabeth Shepherd MSc, "Masking Stress with Misbehavior." This contains important definitions and research underpinning a neurodevelopmental understanding of Self-Regulation, where challenges with a child's ability to regulate biopsychosocial interactions are commonly mistakenly defined as, "Misbehavior." https://selfregulationinstitute.org/reframed-volume-1-issue-1-july-2017-masking-stress-misbehaviour/
The following is a brief but essential overview of the six core strengths necessary for healthy child development by Dr. Bruce Perry, American psychiatrist, currently the Senior Fellow of the Child Trauma Academy in Houston, Texas and an Adjunct Professor of Psychiatry and Behavioral Sciences at the Feinberg School of Medicine in Chicago, Illinois,
The following is an extraordinarily important video clip with regards to a well-known experiment by internationally acclaimed, Developmental psychologist, Edward Tronick, Director of Child Development Unity and Distinguished Professor at University Massachusetts,, Boston. He is a research associate in Newborn Medicine, a lecturer at Harvard Medical School. He is well known for his research on infant/child caregiver dyadic attachment and what transpires when that emotional connection is disrupted or withdrawn: The Still Face Paradigm:
The following video clip, "Attunement and Why It Matters", by David E. Arrendondo, M.D., briefly illustrates what happens between infant/primary caregiver with respect to neuronal connectivity and attunement during deepening reciprocal attachment and emerging co-emotional signaling.
Below is one of the most important seminal papers written in 2004 by the late Stanley Greenspan, M.D. with respect to the role of affect (or the emotions) constituting typical and non-typical developmental pathways. It is absolutely critical reading:
"Developmental Pathways To and From Autism: The Role of Emotions in the Core Deficit in Autistic Spectrum Disorders-- The Affect Diathesis Hypothesis."
Below are two very brief video clip introductions on the "Mirror Neuron System", by Dr. Dan Siegal, Distinguished Fellow of the American Psychiatric Association and is the Executive Director of the Mindsight Institute. Founding Co-Director of the UCLA Mindful Awareness Research Center. He serves as the Medical Director of the Lifespan Learning Institute. The mirror neuron system is largely regarded as challenged with many individuals diagnosed with ASD. It is part of the brain directly responsible for the ability of individuals to empathically identify, register, interpret, understand and predict the "intentionality" of another's action or what has been traditionally referred to as "Theory of Mind."
Dr. Dan Siegal presents below an in-depth discussion on interpersonal neurobiology, "The Neurological Basis of Behavior, the Mind, the Brain and Human Relationships."
Dr. Stephen Porges, Polyvagal Theory: Co-Regulation in Therapy
Dr. Steven Porges, Human Nature and Early Experience (an in-depth discussion on the neurophysiological correlates that constitute the foundation for a biopsychosocial understanding on how typical and non-typical infants begin to learn, grow and thrive.)
Dr. Stephen Porges: The Neuroscience and the Power of Safe Relationships (self regulation/co-regulation)
Dr. Stephen Porges Website: Infant Developmental Update Study
Dr. Stephen Porges: "The Polyvagal Theory."
Dr. Stephen Porges, 2011, Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, Communication and Self-Regulation.
*The following is an extremely important link for all primary caregivers and clinicians with respect to advocacy for their children, intervention guidance, ,public policy, insurance coverage and the adjoining supportive research evidence for a comprehensive Developmental Relationship based approach such as DIR/Floortime, as well as included are answers to common questions from families on ABA which is distortedly presented as the only evidenced-based treatment approach for children with ASD and related challenges.